Human Beta-site APP-Cleaving Enzyme 1,BACE1 ELISA KIT

SKU: E0802Hu

Size:96 Tests-1 Kit

Background:Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity). {ECO:0000250|UniProtKB:P56818, ECO:0000269|PubMed:10656250, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:20354142}.

Research_area:

Applications:ELISA

Target_protein:BACE1

Reactivity:Human

Assay type:Sandwich

Sensitivity:11.39ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:β-site APP-Cleaving Enzyme 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P56817

MASS(Da):55764

GeneID:23621

Synonyms:BACE1 BACE KIAA1149

Gene names:BACE1

Standard solution:6400ng/L