Human Apoptosis Regulator Bax, BAX ELISA Kit

SKU: E4977Hu

Size:96 Tests-1 Kit

Background:Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Research_area:Cell Biology

Applications:ELISA

Target_protein:BAX

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.26ng/ml

Detection range:0.5-150ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Apoptosis regulator BAX

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q07812

MASS(Da):21,184

GeneID:581

Synonyms:Apoptosis regulator BAX;BAX;BCL2L4;Bcl2-L-4;Bcl-2-like protein 4

Gene names:BAX

Standard solution:160ng/ml