Human Alpha-2-Macroglobulin-like Protein 1, A2ML1 ELISA Kit

SKU: E4926Hu

Size:96 Tests-1 Kit

Background:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a Peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

Research_area:Others

Applications:ELISA

Target_protein:A2ML1

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.29ng/mL

Detection range:5-1000ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Alpha-2-Macroglobulin-Like Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:A8K2U0

MASS(Da):161,107

GeneID:144568

Synonyms:A2ML1;Alpha-2-macroglobulin-like protein 1;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9

Gene names:A2ML1

Standard solution:1280ng/mL