Human ALK-1/ACVRL1 ELISA Kit PicoKine®

SKU: EK1518

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: ACVRL1

Specificity: Natural and recombinant human ALK-1

Background: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Immunogen: Expression system for standard: NS0; Immunogen sequence: D22-Q118

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Reference:

Uniprot ID: P37023

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 94

Protein Name: Activin receptor type-1-like

Gene Full Name: activin A receptor like type 1

Synonyms: Activin receptor like kinase 1; ACVRL1; ACVRLK1; ALK 1; ALK1; HHT; HHT2; ORW2; SKR3; TSR I