Human Actin-related Protein 3, ACTR3 ELISA Kit

SKU: E4623Hu

Size:96 Tests-1 Kit

Background:ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed: 9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed: 9000076). Seems to contact the pointed end of the daughter actin filament (PubMed: 9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed: 29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed: 17220302, PubMed: 29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed: 29925947). Plays a role in ciliogenesis (PubMed: 20393563).

Research_area:Others

Applications:ELISA

Target_protein:ACTR3

Reactivity:Human

Assay type:Sandwich

Sensitivity:12.05ng/L

Detection range:20-4000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Actin-Related Protein 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P61158

MASS(Da):47,371

GeneID:10096

Synonyms:Actin-like protein 3;Actin-related protein 3;ACTR 3;ACTR3

Gene names:ACTR3

Standard solution:4800ng/L