Human Acetyl-CoA Carboxylase 2, ACACB ELISA Kit

SKU: E3173Hu

Size:96 Tests-1 Kit

Background:Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed: 16854592, PubMed: 19236960, PubMed: 20457939, PubMed: 20952656, PubMed: 19900410, PubMed: 26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed: 19236960, PubMed: 20457939, PubMed: 20952656, PubMed: 26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:ACACB

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Acetyl-Coa Carboxylase 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O00763

MASS(Da):276,541

GeneID:32

Synonyms:ACACB;ACC-beta;Acetyl-CoA carboxylase 2

Gene names:ACACB

Standard solution:32ng/ml