HSD17B1 Polyclonal Antibody

SKU: E-AB-16497

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: HSD17B1

Target Synonym: 17 beta HSD 1;17 beta hydroxysteroid dehydrogenase type 1;17-beta-HSD 1;17-beta-hydroxysteroid dehydrogenase type 1;20 alpha-hydroxysteroid dehydrogenase;20-alpha-HSD;DHB1;E17KSR;E2DH;EDH17B1;EDH17B2;EDHB17;Estradiol 17 beta dehydrogenase 1;Estradiol 17-beta-dehydrogenase 1;HSD17;HSD17B1;Hydroxysteroid (17 beta) dehydrogenase 1;MGC13814;Placental 17 beta hydroxysteroid dehydrogenase;Placental 17-beta-hydroxysteroid dehydrogenase;SDR28C1;Short chain dehydrogenase/reductase family 28CE;member 1

Research Areas: Cancer;Metabolism;Neuroscience;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P14061

Accession:

Background: Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy.

Concentration: 0.5 mg/mL

Immunogen: Synthetic peptide of human HSD17B1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:50-1:200

Calculated MW: 35kDa

ObservedMW: