HRAS Polyclonal Antibody

SKU: E-AB-53241

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:HRAS

Target Synonym:C BAS/HAS;c H ras;C HA RAS1;c has/bas p21 protein;c ras Ki 2 activated oncogene;c-H-ras;CTLO;GTP and GDP binding peptide B;GTPase HRas;N-terminally processed;H Ras 1;H RASIDX;H-Ras-1;Ha Ras;Ha Ras1 proto oncoprotein;Ha-Ras;HAMSV;Harvey rat sarcoma viral oncogene homolog;Harvey rat sarcoma viral oncoprotein;HRAS;HRAS1;K ras;N ras;p19 H RasIDX protein;p21ras;Ras family small GTP binding protein H Ras;RASH;RASH1;Transformation gene oncogene HAMSV;Transforming protein p21;v Ha ras Harvey rat sarcoma viral oncogene homolog;VH Ras;vHa RAS

Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P01112

Accession:

Background:This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Concentration:0.66 mg/mL

Immunogen:Synthetic peptide of human HRAS

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:WB 1:500-1:2000;IHC 1:25-1:50

Calculated MW:21 kDa

ObservedMW:Refer to figures