Histamine H1 Receptor (phospho Ser398) rabbit pAb

SKU: ES5776

Size: 100μL

Source:Rabbit

Applications:IF;ELISA

Reactivity:Human;Mouse;Rat

Dilution:Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human Histamine H1 Receptor around the phosphorylation site of Ser398. AA range:364-413

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:3269

Human_swiss_prot_no:P35367

Subcellular_location:Cell membrane ; Multi-pass membrane protein .

Other_name:HRH1; Histamine H1 receptor; H1R; HH1R

Background:Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by Ref