HDAC3(Phospho Ser424) Polyclonal Antibody

SKU: BT-AP06575

Size:100μL

Background:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Research_area:Cancer; Cardiovascular; Epigenetics and nuclear signaling; Metabolism; Stem cells

Target_protein:HDAC3

applications:WB, IHC-p, IF, ICC, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Histone deacetylase 3

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):48848

UniProt accession:Human: O15379; Mouse: O88895; Rat: Q6P6W3

Synonyms:Histone deacetylase 3; HDAC3; Histone deacetylase 3; HD3; RPD3 2; RPD3-2; SMAP45

GeneID:Human: 8841; Rat: 84578