GRIA2 Polyclonal Antibody

SKU: E-AB-52034

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: GRIA2

Target Synonym: AMPA 2;AMPA selective glutamate receptor 2;AMPA-selective glutamate receptor 2;AMPA2;GluA2;GLUR 2;GLUR B;GluR K2;GluR-2;GluR-B;GluR-K2;GLUR2;GLURB;Glutamate receptor 2;Glutamate receptor ionotropic AMPA 2;Glutamate receptor ionotropic;Gria2;GRIA2;HBGR2

Research Areas: Cancer;Neuroscience

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P42262

Accession:

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Concentration: 1.08 mg/mL

Immunogen: Synthetic peptide of human GRIA2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:40-1:200

Calculated MW:

ObservedMW: