GPS1 Antibody - Cat. #: CSB-PA615663ESR2HU

SKU: CSB-PA615663ESR2HU

Size :50ul

Clone Number:

Aliases:COP9 signalosome complex subunit 1 antibody; COP9 signalosome subunit 1 antibody; COPS1 antibody; CSN 1 antibody; CSN1_HUMAN antibody; FUS6/COP11; Arabidopsis; homolog of antibody; G protein pathway suppressor 1 antibody; GPS-1 antibody; Gps1 antibody; JAB1-containing signalosome subunit 1 antibody; Protein GPS1 antibody; Protein MFH antibody; SGN1 antibody; Signalosome subunit 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13098

Immunogen:Recombinant Human COP9 signalosome complex subunit 1 protein (222-491AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:GPS1

Research Areas:Neuroscience; Cell biology; Signal transduction