FZD10 Antibody, Biotin conjugated - Cat. #: CSB-PA891782LD01HU

SKU: CSB-PA891782LD01HU

Size :50ug

Clone Number:

Aliases:CD 350 antibody; CD 350 antigen antibody; CD350 antibody; Frizzled (Drosophila) homolog 10 antibody; Frizzled-10 antibody; FZ 10 antibody; Fz-10 antibody; FZ10 antibody; FZD 10 antibody; FZD10 antibody; FZD10_HUMAN antibody; FzE 7 antibody; FzE7 antibody; hFz 10 antibody; hFz10 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9ULW2

Immunogen:Recombinant Human Frizzled-10 protein (125-225AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FZD10

Research Areas:Epigenetics and Nuclear Signaling; Signal transduction; Stem cells