FOXD3 Monoclonal Antibody

SKU: BT-MCA2153

Size:100μL

Background:FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation. FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures. FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.

Research_area:Neuroscience

Target_protein:FOXD3

applications:WB, IHC

Reactivity:Human, Mouse, Monkey

Clonality:Monoclonal

Clone ID:5G9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:FOXD3

Immunogen:Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):50kDa

UniProt accession:Q9UJU5

Synonyms:AIS1, HFH2, Genesis, FOXD3

GeneID:27022