FBXL2 Antibody - Cat. #: CSB-PA892134LA01HU

SKU: CSB-PA892134LA01HU

Size :50ug

Clone Number:

Aliases:DKFZP564P0622 antibody; F box and leucine rich repeat protein 2 antibody; F box protein containing leucine rich repeats antibody; F box protein FBL2/FBL3 antibody; F box/LRR repeat protein 2 antibody; F-box and leucine-rich repeat protein 2 antibody; F-box protein FBL2/FBL3 antibody; F-box/LRR-repeat protein 2 antibody; FBL 2 antibody; FBL 3 antibody; FBL2 antibody; FBL3 antibody; FBXL 2 antibody; FBXL2 antibody; FBXL2_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UKC9

Immunogen:Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200

Background:Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FBXL2

Research Areas:Epigenetics and Nuclear Signaling