FAS/CD95 antibody , Cat. # FNab03017

SKU: FNab03017

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:4B6

Isotype:IgG2a

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Fas(CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.

Immunogen:Fas(TNF receptor superfamily, member 6)

Synonyms:ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6

Observed MW:38-45 kDa

Uniprot ID:P25445

Reactivity:Human, Mouse

Tested Application:ELISA, WB, FC,IHC

Recommended dilution:WB: 1:1000-1:8000; IHC: 1:50-1:500

Gene ID:355

Research Area:Cancer, Immunology, Cardiovascular, Signal Transduction