F8 Monoclonal Antibody

SKU: BT-MCA2968

Size:100μL

Background:F8: coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Research_area:Cardiovascular

Target_protein:F8

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:5E9B2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:F8

Immunogen:Purified recombinant fragment of F8 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P00451

Synonyms:AHF, F8B, F8C, HEMA, FVIII

GeneID:2157