F Antibody - Cat. #: CSB-PA356041LA01HTO

SKU: CSB-PA356041LA01HTO

Size :50ug

Clone Number:

Aliases:F antibody; Fusion glycoprotein F0 antibody; Protein F) [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion glycoprotein F2; Fusion glycoprotein F1] antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human) respiratory syncytial virus A (strain A2)

UniProt ID:P03420

Immunogen:Recombinant Human respiratory syncytial virus A Fusion glycoprotein F0 protein (27-529AA)

Raised in:Rabbit

Species Reactivity:Human respiRatory syncytial virus A

Tested Applications:ELISA

Background:During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2 (PubMed:18216092). Interacts directly with heparan sulfate and may participates in virus attachment (PubMed:10864656). Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity (PubMed:11493675). Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis (PubMed:12663767).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:F

Research Areas:Others