Ezrin/villin 2/EZR Monoclonal Antibody

SKU: AN200221P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:EZR

Target Synonym:HEL;IMD;MGC;DFNB;DKFZp762H;Epididymis secretory protein Li;HEL-S;HEL S;VIL;CVL;CVIL;VIL2;HEL-S-105;DFNB24;HEL70;IMD50;Cytovillin;Cytovillin 2;DKFZp762H157;Epididymis secretory protein Li 105;EZRI;Ezrin;FLJ26216;HEL S 105;MGC1584;p81;VIL 2;Villin 2;Villin 2 (ezrin);Villin 2 ezrin;Villin2;Villin-2;EZR

Research Areas:Signal Transduction;Cancer

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB;IP

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:4B4

UNIProt ID:P15311

Accession:

Background:The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.

Concentration:1 mg/mL

Immunogen:Recombinant Human Ezrin/villin 2/EZR Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:1000;IP 0.1-0.5 μL/mg of lysate

Calculated MW:69 kDa

ObservedMW:90 kDa