ESPL1 Polyclonal Antibody

SKU: E-AB-16415

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: ESPL1

Target Synonym: Caspase like protein ESPL1;Caspase-like protein ESPL1;ESP 1;ESP1;ESPL 1;Espl1;ESPL1;Extra spindle poles like 1;Extra spindle poles like 1 protein;Extra spindle poles-like 1 protein;FLJ46492;KIAA0165;Separase;Separin;Similar to fission yeast cut1and gene;SSE

Research Areas: Cancer;Cell biology;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q14674

Accession:

Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.

Concentration: 1 mg/mL

Immunogen: Synthetic peptide of human ESPL1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: