ERAP1 Antibody - Cat. #: CSB-PA987708

SKU: CSB-PA987708

Size :100ul

Clone Number:

Aliases:A LAP antibody; A-LAP antibody; Adipocyte derived leucine aminopeptidase antibody; Adipocyte-derived leucine aminopeptidase antibody; ALAP antibody; Aminopeptidase PILS antibody; Aminopeptidase regulator of TNFR1 shedding antibody; APPILS antibody; ARTS 1 antibody; ARTS-1 antibody; Arts1 antibody; Endoplasmic reticulum aminopeptidase 1 antibody; Endoplasmic reticulum aminopeptidase associated with antigen processing antibody; ERAAP antibody; ERAAP1 antibody; ERAP 1 antibody; Erap1 antibody; ERAP1_HUMAN antibody; KIAA0525 antibody; kiaa0525 protein antibody; PILS AP antibody; PILS-AP antibody; PILSA antibody; PILSAP antibody; Puromycin insensitive leucyl specific aminopeptidase antibody; Puromycin-insensitive leucyl-specific aminopeptidase antibody; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator antibody; type 1 tumor necrosis factor receptors shedding aminopeptidase regulator antibody; VEGF-induced aminopeptidase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NZ08

Immunogen:Synthesized peptide derived from internal of Human ARTS-1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Hattori A., J. Biochem. 130:235-241(2001).
Nakajima D., DNA Res. 9:99-106(2002).
Clark H.F., Genome Res. 13:2265-2270(2003).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ERAP1

Research Areas:Cardiovascular?Cell biology;Immunology