EGLN1 Antibody - Cat. #: CSB-PA863932ESR2HU

SKU: CSB-PA863932ESR2HU

Size :50ul

Clone Number:

Aliases:C1ORF12 antibody; Chromosome 1 Open Reading Frame 12 antibody; DKFZp761F179 antibody; ECYT 3 antibody; ECYT3 antibody; Egl 9 family hypoxia inducible factor 1 antibody; EGL 9 homolog of C. elegans 1 antibody; EGL nine (C.elegans) homolog 1 antibody; Egl nine homolog 1 (C. elegans) antibody; Egl nine homolog 1 antibody; Egl nine like protein 1 antibody; EGLN 1 antibody; Egln1 antibody; EGLN1_HUMAN antibody; HIF PH2 antibody; HIF Prolyl Hydroxylase 2 antibody; HIF-PH2 antibody; HIF-prolyl hydroxylase 2 antibody; HIFP4H 2 antibody; HIFPH2 antibody; HPH 2 antibody; HPH-2 antibody; HPH2 antibody; Hypoxia inducible factor prolyl hydroxylase 2 antibody; Hypoxia-inducible factor prolyl hydroxylase 2 antibody; ORF13 antibody; P4H2 antibody; PHD 2 antibody; PhD2 antibody; PNAS 118 antibody; PNAS 137 antibody; Prolyl Hydroxylase Domain Containing Protein 2 antibody; Prolyl hydroxylase domain-containing protein 2 antibody; Rat Homolog of SM20 antibody; SM 20 antibody; SM-20 antibody; SM20 antibody; Zinc finger MYND domain containing protein 6 antibody; ZMYND6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9GZT9

Immunogen:Recombinant Human Egl nine homolog 1 protein (301-426AA)

Raised in:Rabbit

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background:Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recognized via a LXXLAP motif.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:EGLN1

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism