DSCAM Antibody, HRP conjugated - Cat. #: CSB-PA007192LB01HU

SKU: CSB-PA007192LB01HU

Size :50ug

Clone Number:

Aliases:CHD2 42 antibody; CHD2 52 antibody; CHD2 antibody; Down syndrome cell adhesion molecule antibody; DSCAM antibody; DSCAM_HUMAN antibody; human CHD2-52 down syndrome cell adhesion molecule 2; 9 antibody; OTTHUMP00000109193 2 antibody; SD11109p antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O60469

Immunogen:Recombinant Human Down syndrome cell adhesion molecule protein (1711-1867AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DSCAM

Research Areas:Neuroscience