Doublecortin/DCX Monoclonal Antibody

SKU: AN200080P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:DCX

Target Synonym:DBCN;DC;LISX;SCLH;XLIS;DCX;Dbct;Doublecortex;doublecortin;Doublin;FLJ51296;Lis X;Lissencephalin X;Lissencephalin-X;Lissencephaly X linked;Lissencephaly X linked doublecortin;Lis-X;Neuronal migration protein doublecortin;OTTHUMP00000023859;OTTHUMP00000023860;OTTHUMP00000216315;OTTHUMP00000216316

Research Areas:Neuroscience;Tags & Cell Markers

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:ICC/IF

Isotype:IgG2a

Clonality:Monoclonal

Clone NO.:2D7

UNIProt ID:O43602

Accession:

Background:This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Concentration:1 mg/mL

Immunogen:Recombinant Human Doublecortin/DCX Protein

Buffer:0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0

Purification method:Protein A

Dilution:ICC/IF 1:20-1:100;

Calculated MW:

ObservedMW: