DOCK7 antibody , Cat. # FNab02497

SKU: FNab02497

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.

Immunogen:dedicator of cytokinesis 7

Synonyms:dedicator of cytokinesis 7, DOCK7, KIAA1771, ZIR2

Observed MW:240 kDa

Uniprot ID:Q96N67

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IP

Recommended dilution:WB: 1:200-1:1000; IP: 1:500-1:1000

Gene ID:85440

Research Area:Neuroscience, Developmental biology