DNA-RNA Hybrid Monoclonal Antibody[S9.6]

SKU: E-AB-48028

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:DNA-RNA Hybrid

Target Synonym:DNA-RNA hybrid;RNA/DNA hybrid

Research Areas:

Conjugation:Unconjugated

Host:Mouse

Species reactivity:All

Application:IF;ChIP

Isotype:IgG2a

Clonality:

Clone NO.:S9.6

UNIProt ID:

Accession:

Background:The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNA?RNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since R?loop sequence affects binding affinity.

Concentration:1 mg/mL

Immunogen:ΦX174 bacteriophage-derived synthetic DNA/RNA

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Protein A/G Purification

Dilution:IF 1:200;ChIP 1:50-500;

Calculated MW:

ObservedMW: