DDIT4 Antibody - Cat. #: CSB-PA151075

SKU: CSB-PA151075

Size :50ul

Clone Number:

Aliases:DDIT4 antibody; DDIT4_HUMAN antibody; Dig2 antibody; DNA damage inducible transcript 4 antibody; DNA damage inducible transcript 4 protein antibody; DNA damage-inducible transcript 4 protein antibody; FLJ20500 antibody; HIF 1 responsive protein RTP801 antibody; HIF 1 responsive RTP801 antibody; HIF-1 responsive protein RTP801 antibody; Protein regulated in development and DNA damage response 1 antibody; REDD-1 antibody; REDD1 antibody; RTP801 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NX09

Immunogen:Fusion protein of Human DDIT4

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:50-1:200

Background:REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DDIT4

Research Areas:Epigenetics and Nuclear Signaling;Cancer?Cardiovascular;Metabolism