Cystatin E/CST6 Monoclonal Antibody

SKU: AN200026P

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Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:CST6

Target Synonym:CST 6;Cystatin 6;Cystatin E;Cystatin E/M;Cystatin M;Cystatin M/E;Cystatin6;Cystatin-6;CystatinE;Cystatin-E;CystatinM;Cystatin-M;Cysteine proteinase inhibitor;CYTM;CST6

Research Areas:Cell Biology

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:IHC-P

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:6G11

UNIProt ID:Q15828

Accession:

Background:Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.

Concentration:1 mg/mL

Immunogen:Recombinant Human Cystatin E / CST6 protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:IHC-P 1:50-1:200;

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