CXCR2 Antibody - Cat. #: CSB-PA282080

SKU: CSB-PA282080

Size :50ul

Clone Number:

Aliases:C-X-C chemokine receptor type 2 antibody; CD 182 antibody; CD182 antibody; CD182 antigen antibody; CDw128b antibody; Chemokine (CXC) receptor 2 antibody; CMKAR2 antibody; CXC-R2 antibody; CXCR 2 antibody; CXCR-2 antibody; CXCR2 antibody; CXCR2_HUMAN antibody; GRO/MGSA receptor antibody; High affinity interleukin-8 receptor B antibody; IL 8 receptor type 2 antibody; IL 8R B antibody; IL-8 receptor type 2 antibody; IL-8R B antibody; IL8 RB antibody; IL8 receptor type 2 antibody; IL8R B antibody; IL8R2 antibody; IL8RA antibody; Interleukin 8 Receptor B antibody; Interleukin 8 receptor; beta antibody; Interleukin 8 receptor; type 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P25025

Immunogen:Synthetic peptide of Human CXCR2

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; ELISA:1:1000-1:2000, WB:1:200-1:1000

Background:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CXCR2

Research Areas:Cell biology;Signal transduction