CTDSP1 Antibody - Cat. #: CSB-PA131500

SKU: CSB-PA131500

Size :100ul

Clone Number:

Aliases:Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody; CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1 antibody; CTD small phosphatase 1 antibody; CTDS1_HUMAN antibody; CTDSP1 antibody; NIF3 antibody; NLI IF antibody; NLI interacting factor 3 antibody; NLI-IF antibody; NLI-interacting factor 3 antibody; NLIIF antibody; Nuclear LIM interactor interacting factor 3 antibody; Nuclear LIM interactor-interacting factor 3 antibody; SCP1 antibody; Small C-terminal domain phosphatase 1 antibody; Small CTD phosphatase 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9GZU7

Immunogen:Synthesized peptide derived from N-terminal of Human CTDSP1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Marquet S., Mamm. Genome 11:755-762(2000).
Yeo M., J. Biol. Chem. 278:26078-26085(2003).
Hillier L.W., Nature 434:724-731(2005)

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CTDSP1

Research Areas:Epigenetics and Nuclear Signaling;Signal transduction