COPS7B Antibody, HRP conjugated - Cat. #: CSB-PA872526LB01HU

SKU: CSB-PA872526LB01HU

Size :50ug

Clone Number:

Aliases:COP9 Complex Homolog Subunit 7b antibody; COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody; COP9 Signalasome Subunit 7b antibody; COP9 signalosome complex subunit 7b antibody; COPS7B antibody; CSN7B_HUMAN antibody; JAB1 Containing Signalosome Subunit 7b antibody; JAB1-containing signalosome subunit 7b antibody; SGN7b antibody; Signalosome subunit 7b antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H9Q2

Immunogen:Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:COPS7B

Research Areas:Neuroscience; Signal transduction