COPS2 Antibody - Cat. #: CSB-PA231077

SKU: CSB-PA231077

Size :100ul

Clone Number:

Aliases:ALIEN antibody; Alien Drosophila himolog of antibody; Alien homolog antibody; COP 9 antibody; COP9 antibody; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody; COP9 constitutive photomorphogenic homolog subunit 2 antibody; COP9 signalosome complex subunit 2 antibody; COPS 2 antibody; Cops2 antibody; CSN2 antibody; CSN2_HUMAN antibody; JAB1 containing signalosome subunit 2 antibody; JAB1-containing signalosome subunit 2 antibody; SGN 2 antibody; SGN2 antibody; Signalosome subunit 2 antibody; Thyroid Hormone Receptor Interactor15 antibody; Thyroid Hormone Receptor Interactor 15 antibody; Thyroid receptor-interacting protein 15 antibody; TR-interacting protein 15 antibody; TRIP 15 antibody; TRIP-15 antibody; TRIP15 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P61201

Immunogen:Synthesized peptide derived from internal of Human COPS2.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500

Background:Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Lee J.W., Mol. Endocrinol. 9:243-254(1995).
Dressel U., Mol. Cell. Biol. 19:3383-3394(1999).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:COPS2

Research Areas:Epigenetics and Nuclear Signaling;Signal transduction