Collagen I alpha 1 (Cleaved-Ala1218) Rabbit Polyclonal Antibody

SKU: BT-AP01759

Size:100μL

Background:This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone| cornea| dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV| Ehlers-Danlos syndrome type VIIA| Ehlers-Danlos syndrome Classical type| Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22| where this gene and the gene for platelet-derived growth factor beta are located| are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans| resulting from unregulated expression of the growth factor. Two transcripts| resulting from the use of alternate polyadenylation signals| have been identified for this gene.

Research_area:Signal transduction; Stem cells

Target_protein:COL1A1

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Collagen I alpha 1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):161040

UniProt accession:Human: P02452; Mouse: P11087; Rat: P02454

Synonyms:Collagen I α1 ;Cleaved-Ala1218; Collagen alpha-1;I chain; Alpha-1 type I collagen

GeneID:Human: 1277; Mouse: 12842; Rat: 29393