Cleaved-Caspase-1 p20 (D210) rabbit pAb

SKU: ES7675

Size: 100μL

Source:Rabbit

Applications:WB;IF;IHC;ELISA

Reactivity:Human;Mouse;Rat

Dilution:WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300

Immunogen:The antiserum was produced against synthesized peptide derived from human Caspase-1. AA range:161-210

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):25kD

Human_gene_id:834

Human_swiss_prot_no:P29466

Subcellular_location:Cytoplasm . Cell membrane .

Other_name:CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45

Background:This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],