Claudin18.2 Monoclonal Antibody

SKU: AN200149P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:CLDN18

Target Synonym:UNQ;PRO;CLDN;SFTA;Claudin;Claudin-;CLDN18;SFTA5;SFTPJ;Claudin-18;Claudin-18.2;UNQ778;PRO1572;SPJ

Research Areas:Signal Transduction

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB;IHC-P

Isotype:IgG2a

Clonality:Monoclonal

Clone NO.:10C12

UNIProt ID:P56856

Accession:

Background:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-2) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Concentration:1 mg/mL

Immunogen:Human Claudin18.2 mRNA

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;IHC-P 1:500-1:2000;

Calculated MW:

ObservedMW: