CK19 Mouse mAb

SKU: EM1051

Size: 100μL

Source:Mouse

Applications:IHC

Reactivity:Human, Rat, Mouse

Dilution:IHC 1:200

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):44kDa

Human_gene_id:3880

Human_swiss_prot_no:P08727

Subcellular_location:Cytoskeleton,Cytosol

Other_name:Cytokeratin 19, K19, K1CS, keratin 19, KRT19

Background:This protein is a member of the keratin family. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Keratin 19 is not expressed in hepatocytes, therefore, antibody to keratin 19 is useful in the identification of liver metastasis. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7.