CIDEC Antibody - Cat. #: CSB-PA842636ESR1HU

SKU: CSB-PA842636ESR1HU

Size :50ul

Clone Number:

Aliases:Cell death activator antibody; Cell death activator CIDE-3 antibody; Cell death inducing DFFA like effector C antibody; Cell death inducing DFFA like effector protein C antibody; Cell death-inducing DFFA-like effector protein C antibody; CIDE 3 antibody; CIDE C antibody; CIDE3 antibody; CIDEC antibody; CIDEC_HUMAN antibody; Fat specific protein 27 antibody; Fat-specific protein FSP27 homolog antibody; FLJ20871 antibody; FPLD5 antibody; FSP27 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96AQ7

Immunogen:Recombinant Human Cell death activator CIDE-3 protein (1-238AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CIDEC

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Cell biology