CDKN1A Monoclonal Antibody

SKU: BT-MCA3189

Size:100μL

Background:This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

Research_area:Cancer, Cell biology, Epigenetics and nuclear signaling, Signal transduction

Target_protein:CDKN1A

applications:IHC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:2B7F8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CDKN1A

Immunogen:Purified recombinant fragment of human CDKN1A (AA: 1-164) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):18.1kDa

UniProt accession:P38936

Synonyms:P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1

GeneID:1026