CD204 Monoclonal Antibody

SKU: BT-MCA2380

Size:100μL

Background:This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Research_area:Others

Target_protein:CD204

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:5B8H4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD204

Immunogen:Purified recombinant fragment of human CD204 (AA: extra 275-451) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):49.8kDa

UniProt accession:P21757

Synonyms:MSR1, SRA, SR-A, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII

GeneID:4481