CD156B Monoclonal Antibody

SKU: BT-MCA2466

Size:100μL

Background:This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2.

Research_area:Others

Target_protein:CD156B

applications:WB, ICC, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:7A6B2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD156B

Immunogen:Purified recombinant fragment of human CD156B (AA: 497-671) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):93kDa

UniProt accession:P78536

Synonyms:ADAM17, CSVP, TACE, NISBD, ADAM18, , NISBD1

GeneID:6868