CD148 Monoclonal Antibody

SKU: BT-MCA4258

Size:100μL

Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Research_area:Others

Target_protein:CD148

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:1D2C11

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:CD148

Immunogen:Purified recombinant fragment of human CD148 (AA: extra 36-210) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):146kDa

UniProt accession:Q12913

Synonyms:PTPRJ, DEP1, SCC1, HPTPeta, R-PTP-ETA

GeneID:5795