CD125 Monoclonal Antibody

SKU: BT-MCA2346

Size:100μL

Background:The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.

Research_area:Others

Target_protein:CD125

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:5E12F5D6

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD125

Immunogen:Purified recombinant fragment of human CD125 (AA: extra 21-196) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):47.7kDa

UniProt accession:Q01344

Synonyms:IL5RA, IL5R, CDw125, HSIL5R3

GeneID:3568