CASP14 antibody , Cat. # FNab09900

SKU: FNab09900

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Immunogen:CASP14

Synonyms:CASP14, ARCI12, caspase-14

Observed MW:30 kDa

Uniprot ID:P31944

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IF

Recommended dilution:WB: 1:500 - 1:2000; IF: 1:50 - 1:200

Gene ID:23581

Research Area:Cell Division and Proliferation