Canine Fibroblast Growth Factor 1, FGF1 ELISA Kit

SKU: E0237Ca

Size:96 Tests-1 Kit

Background:Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.

Research_area:Cardiovascular; Signal Transduction; Cancer

Applications:ELISA

Target_protein:FGF1

Reactivity:Canine

Assay type:Sandwich

Sensitivity:0.62ng/L

Detection range:1-400ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Fibroblast Growth Factor 1

Species:Canine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P18651

MASS(Da):1,733

GeneID:607724

Synonyms:Acidic fibroblast growth factor;aFGF;ECGF;Endothelial cell growth factor;FGF1;FGF-1;Fibroblast growth factor 1;Fragment;HBGF-1;Heparin-binding growth factor 1

Gene names:FGF1

Standard solution:480ng/L