Bovine IGF-1 ELISA Kit PicoKine®

SKU: EK0376-BV

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Bovine

Applications: ELISA

Application Details:

Gene Name: IGF1

Specificity:

Background: Insulin-like growth factor 1 (IGF-1) that was once called somatomedin C, is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. Bovine IGF1 is a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges, with a calculated molecular mass of 7.6 kD.1 The IGF1 gene, mapped on 12q22-q24. contains 5 exons. Exons 1-4 encode the 195-amino acid precursor (IGF1B), and exons 1, 2, 3, and 5 encode the 153-residue peptide (IGF1A). The structure of IGF1 resembles that of IGF2. And the IGF1 and IGF2 genes have complex structures with multiple promoters. The expression of both genes is regulated at the levels of transcription, RNA processing, and translation. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Moreover, approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). Furthermore, IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: G49-A118

Clonality:

Contents:

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Reconstitution:

Reference:

Uniprot ID: P05019

Host:

Concentration:

Conjugate:

Cross Reactivity: There is no detectable cross-reactivity with IGF-2.

Isotype:

Phospho_site:

Clone Number:

Observed Molecular Weight:

Calculated Molecular Weight:

Gene ID: 281239

Protein Name: Insulin-like growth factor 1

Gene Full Name: insulin like growth factor 1

Synonyms: IBP1; IGF I; IGF1; IGF-1; IGF1A; IGF1B; IGFI; Insulin like growth factor I; Mechano growth factor; MGF; Somatomedin C