BNIP3 Antibody - Cat. #: CSB-PA618642ESR1HU

SKU: CSB-PA618642ESR1HU

Size :50ul

Clone Number:

Aliases:BCL2 Adenovirus E1B 19kDa Interacting Protein 3 antibody; BCL2/adenovirus E1B 19 kDa protein interacting protein 3 antibody; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 antibody; BNIP 3 antibody; BNIP3 antibody; BNIP3_HUMAN antibody; NIP 3 antibody; NIP3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q12983

Immunogen:Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 protein (1-164AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BNIP3

Research Areas:Cancer; Cardiovascular; Cell biology; Metabolism; Microbiology