BHLHE41 Antibody - Cat. #: CSB-PA883658LA01HU

SKU: CSB-PA883658LA01HU

Size :50ug

Clone Number:

Aliases:Basic helix-loop-helix domain containing class B3 antibody; BHE41_HUMAN antibody; bHLH protein DEC2 antibody; bHLHB3 antibody; bHLHe41 antibody; Class B basic helix loop helix protein 3 antibody; Class B basic helix-loop-helix protein 3 antibody; Class E basic helix-loop-helix protein 41 antibody; DEC2 antibody; Differentially expressed in chondrocytes protein 2 antibody; Enhancer of split and hairy related protein 1 antibody; Enhancer-of-split and hairy-related protein 1 antibody; hDEC2 antibody; Moderately similar to basic-helix loop helix protein M.musculus antibody; SHARP-1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9C0J9

Immunogen:Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background:Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5\\\'-CACGTG-3\\\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BHLHE41

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Metabolism; Signal transduction