ARI1A rabbit pAb

SKU: ES9020

Size: 100μL

Source:Rabbit

Applications:IHC;IF

Reactivity:Human;Mouse

Dilution:IHC-p 1:50-300

Immunogen:Synthesized peptide derived from human protein . at AA range: 1270-1350

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):251kD

Human_gene_id:8289

Human_swiss_prot_no:O14497

Subcellular_location:Nucleus .

Other_name:

Background:This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through eit