AR Monoclonal Antibody

SKU: BT-MCA2425

Size:100μL

Background:AR: androgen receptor. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Research_area:Signal Transduction

Target_protein:AR

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:1A9D12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:AR

Immunogen:Purified recombinant fragment of AR (aa689-919) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:P10275

Synonyms:KD, AIS, TFM, DHTR, SBMA

GeneID:367