Anti-TIMELESS Antibody Picoband®

SKU: A00831

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: TIMELESS

Specificity:

Background: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders.

Immunogen: E.coli-derived human TIMELESS recombinant protein (Position: Q72-E1050).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Barnes, J. W., Tischkau, S. A., Barnes, J. A., Mitchell, J. W., Burgoon, P. W., Hickok, J. R., Gillette, M. U. Requirement of mammalian timeless for circadian rhythmicity. Science 302: 439-442, 2003. Note: Erratum: Science 302: 1153 only, 2003. 2. Busza, A., Emery-Le, M., Rosbash, M., Emery, P. Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science 304: 1503-1506, 2004. 3. Chan, R. C., Chan, A., Jeon, M., Wu, T. F., Pasqualone, D., Rougvie, A. E., Meyer, B. J. Chromosome cohesion is regulated by a clock gene paralogue TIM-1. Nature 423: 1002-1009, 2003.

Uniprot ID: Q9UNS1

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 160 kDa

Calculated Molecular Weight: 97214 MW

Gene ID: 8914

Protein Name: Protein timeless homolog

Gene Full Name: timeless circadian regulator

Synonyms: hTIM; Protein timeless homolog; TIM; TIM1; TIMELESS; TIMELESS1